Neuroimaging studies of dyslexia and other complex disorders are often under-powered, in part because of MRI scanning costs and the difficulty of recruiting and carefully selecting participants. Integrating data from existing studies will increase power and provides the opportunity to use the same analysis methods across samples, but there are significant methodological challenges to the success of this approach. Our recently initiated NICHD supported project aims to address some of these challenges that include protection of participant identify, behavioral heterogeneity within and between samples of complex disorders, missing data, and the appropriate statistical pooling of data across samples. Check back soon for more information and please contact us if you would like to contribute to our project (dyslexia AT musc.edu).
A special thanks to Dorothy Bishop for posting information about our project.